Treatment and Prevention

How to use the drug Protafan NM?

Protafan NM is a means by which patients manage to get rid of diabetes, that is, it belongs to the group of hypoglycemic drugs.

International non-proprietary name

Insulin isophane (genetically engineered). Name in Latin: Protaphane.

ATX

A10AC01.

Forms of release and composition

The drug is available with the specified name and name Penfill. The difference is that the second type is placed in cartridges, and the first is placed in a bottle, that is, they have different packaging. 1 bottle contains 10 ml of medication, and this is identical to 1000 IU. In one cartridge 3 ml of medication (300 IU). 1 ml of suspension for subcutaneous administration contains 100 IU of insulin-isophane, which is the active substance.

1 ml of suspension for subcutaneous administration contains 100 IU of insulin-isophane, which is the active substance.

pharmachologic effect

Produced active substance using recombinant DNA biotechnology. Due to the interaction with the special receptor of the external cell membrane and the formation of the complex, it becomes possible to stimulate certain processes inside the cell, which also include the production of the most important enzymes.

The level of glucose in the blood falls due to the fact that the liver begins to produce it in a smaller amount and to the fact that it is absorbed by the tissues to a greater extent. The factors that influence the degree of insulin absorption by the human body are different and include the injection site, the age of the patient and some other indicators.

Affect the body the drug can within a day. It begins to act 1.5 hours after the administration, the highest concentration in the blood is detected 4-12 hours after the active substance enters the body.

Pharmacokinetics

How fully insulin is absorbed depends on the location in which it was decided to inject it, on the dose of medication administered. Injection is allowed in the thigh, buttocks or abdomen.

Protafan NM - helps to get rid of diabetes, belongs to the group of hypoglycemic drugs.

Almost does not bind with plasma proteins. All metabolites that are formed as a result of decomposition reactions are inactive. The half-life is in the range of 5 to 10 hours.

Indications for use

Diabetes mellitus is the only disease that can be treated with this medication. It may be type 1 or type 2 diabetes.

Contraindications

It is impossible to treat a patient with a remedy, in the presence of hypersensitivity to human insulin or hypoglycemia.

Carefully

With violations of adrenal function, diseases of the pituitary gland, thyroid gland, dose adjustment is necessary.

How to take Protaphan NM

With diabetes

Each patient before using the tool should be familiar with the instructions. The drug is intended for individual use. The dose must be selected separately for each patient based on laboratory data.

The dose must be selected separately for each patient based on laboratory data.

Most often, the dose is in the range from 0.3 to 1 IU per 1 kg of patient weight per day. Insulin requirements may be higher in patients with insulin resistance. It most often happens during puberty and in obese people.

The drug can be used as monotherapy, but sometimes it is combined with fast or short-acting insulin and thus made part of a comprehensive treatment.

The introduction is mainly carried out subcutaneously in the femoral region. If it is more comfortable for the patient to give an injection to the shoulder, buttock, or anterior abdominal wall, he can do so. It is important to remember that the drug from the thigh will be absorbed more slowly.

It is not necessary to constantly put injections in the same place, as this can lead to the appearance of lipodystrophies. Do not administer the suspension intravenously.

Side effects of Protafan NM

All adverse reactions when using this drug is considered to be dose-dependent. The most common adverse effect is hypoglycemia. If it is severe, seizures, loss of consciousness, and even death are possible.

In addition to this violation, there may be violations in the functioning of the systems of organs of the patient. If the immune system suffers, rashes and urticaria, shortness of breath and loss of consciousness, and anaphylactic reactions may occur.

Refraction pathologies, peripheral neuropathy, reactions at the injection site become rare side effects. Many of these violations are reversible.

special instructions

Use in old age

It is important to consult with a specialist about the safety of the drug.

If a woman has diabetes before becoming pregnant, and during pregnancy, it is worth continuing the therapy.
During lactation, the drug is not dangerous for an infant.
Children may be prescribed the drug, but you need to conduct special monitoring of their condition during treatment.
It is important for the elderly to consult with a specialist about the safety of the drug.

Purpose Protafan NM children

Children may be prescribed the drug, but you need to conduct special monitoring of their condition during treatment.

Use during pregnancy and lactation

If a woman suffered from diabetes before becoming pregnant, and while carrying a fetus, it is worthwhile to continue drug therapy. This is necessary due to the fact that, in the absence of therapy, fetal health can be injured.

During lactation, the drug is not dangerous for an infant.

Overdose of Protafan NM

If patients are given higher doses of insulin, this can trigger hypoglycemia. If the degree of such a violation is mild, the patient needs to consume sugar or any food that is saturated with carbohydrates. But if the condition has managed to develop to severe, it is necessary to inject a solution of glucagon or dextrose and normalize the diet.

If patients are given higher doses of insulin, this can cause hypoglycemia, you need to eat food that is saturated with carbohydrates.
Reserpine and salicylates can both strengthen and weaken the effect of the drug.
It is better to refuse alcohol while the treatment is underway, since it may enhance the hypoglycemic effect of insulin.

Interaction with other drugs

Reserpine and salicylates can both strengthen and weaken the effect of the drug.

Cyclophosphamide, anabolic steroids, lithium preparations, bromocriptine, monoamine oxidase inhibitors can enhance the effect of the active substance. Weaken the activity of the drug clonidine, morphine, danazol, heparin and oral contraceptives, phenytoin.

Compatibility with alcohol

It is better to refuse alcohol while the treatment is underway, since it may enhance the hypoglycemic effect of insulin.

Analogs

Biosulin N, Infuman Bazal GT.

How to use the Insulin® Basal GT insulin syringe pen
Insulin drug Isofan (Insulin Isofan)

Pharmacy vacation terms

Can I buy without a prescription

This is not possible, a prescription from a doctor is needed.

Price for Protafan NM

From 400 rubles.

Drug storage conditions

At a temperature condition from 2 ° C to 8 ° C.

Shelf life

30 months.

Manufacturer

Novo Nordisk A / S, Novo-Allais. DK-2880 Bagsvaird, Denmark.

An analogue of the drug Protafan NM may be the means of Biosulin N.

Reviews Protafane NM

Karina, 38, Rostov-on-Don: “I have been treated with this remedy not so long ago. I recommend with certainty to those who have experienced diabetes. It is clear that without medical instructions you cannot use the medicine, and from pharmacies it is released only if you have doctor’s prescription. But it is possible and convenient to apply the product at home, as detailed instructions are attached to it. "

Anton, 50 years old, Moscow: “The use of the drug allows you to keep the body in a stable condition. It’s impossible to completely get rid of the pathology, but hope remains. The insulin shots allow you to keep the glucose concentration at an optimal level. Periodically, I see a doctor and I can work and live in peace. Without this medicine, it would hardly have been possible. So I can advise him to everyone. "

Kirill, 30 years old, Zheleznogorsk: “They prescribed this medicine a few weeks ago. I had to appear as a doctor, as my diabetes-like symptoms began to torment me not so long ago. I thought that I had encountered this disease. After consulting with a specialist and having passed the necessary tests, this was confirmed. The doctor reassured him and said that it was possible to treat the pathology.

This drug was prescribed. Injections put at home on their own. This is easy to do, as detailed instructions are included with the drug describing the entire sequence of actions. I feel that the negative symptoms go away. "

Watch the video: How to Use an Insulin Pen - Mayo Clinic Patient Education (November 2019).

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